Condensação de Knoevenagel de aldeídos aromáticos com o ácido de Meldrum em água: uma aula experimental de Química Orgânica Verde

Química Nova

Silvio Cunha¹  Lourenço Luis Botelho De Santana¹ 

[1] ,Universidade Federal da Bahia Instituto de Química Salvador BA

关键词: arylidene Meldrum's acid;    undergraduate organic chemistry experiment;    green chemistry;   

DOI  :  10.1590/S0100-40422012000300036

来源: SciELO

【 摘 要 】

This work describes an undergraduate experiment for the synthesis of Knoevenagel adduct of Meldrum's acid with nine aromatic aldehydes, using water as the solvent, in an adaptation of a previously reported synthetic protocol. The synthesis was straightforward, requiring a period of two hours, and is suitable for undergraduate experimental courses on green chemistry. In addition, quantitative analyses of the relative reactivity of p-nitro-benzaldehyde and p-metoxi-benzaldehyde was evaluated through the competitive reaction of equimolar amounts of these aldehydes with one equivalent of Meldrum's acid, using gas chromatography to quantify the composition of the reaction mixture.

【 授权许可】

CC BY-NC   
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