Efficient synthesis of sulfonamide derivatives on solid supports catalyzed using solvent-free and microwave-assisted methods

Química Nova

Argelia Camargo-ordoñez¹  Christian Moreno-reyes¹  Fabián Olazarán-santibáñez¹  Sheila Martínez-hernández¹  Virgilio Bocanegra-garcía¹  Gildardo Rivera¹ 

[1] ,Universidad Autónoma de Tamaulipas Departamento de Farmacia y Química Medicina México

关键词: synthesis;    sulfonamide;    solid supports;   

DOI  :  10.1590/S0100-40422011000500011

来源: SciELO

【 摘 要 】

In this work we report the synthesis of sulfonamide derivatives using a conventional procedure and with solid supports, such as silica gel, florisil, alumina, 4Å molecular sieves, montmorillonite KSF, and montmorillonite K10 using solvent-free and microwave-assisted methods. Our results show that solid supports have a catalytic activity in the formation of sulfonamide derivatives. We found that florisil, montmorillonite KSF, and K10 could be used as inexpensive alternative catalysts that are easily separated from the reaction media. Additionally, solvent-free and microwave-assisted methods were more efficient in reducing reaction time and in increasing yield.

【 授权许可】

CC BY-NC   
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