Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes

Química Nova

Érica L. Santos²  Emmanoel V. Costa²  Francisco A. Marques²  Nelissa P. Vaz²  Beatriz Helena L. N. Sales Maia²  Eva G. Magalhães¹  Ana Maria A. Tozzi¹ 

[1] ,Universidade Federal do Paraná Departamento de Química Curitiba PR ,Brasil

关键词: Lonchocarpus filipes;    flavonoids;    dibenzoylmethanes;   

DOI  :  10.1590/S0100-40422009000900002

来源: SciELO

【 摘 要 】

The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data (¹H and 13C NMR, 2D-NMR) as being: lanceolatin B (1), pongamol (2), (E)-7-O-methylpongamol (3) and (E)-9-O-methylpongamol (4). Compound (4) is described herein for the first time as a natural product. The extracts and the isolated compounds (1), (2) and (3) displayed high toxicity in the brine shrimp lethality assay. Only compound (2) showed antioxidant activity using a DPPH radical scavenging assay. This is the first report on the phytochemical study of Lonchocarpus filipes.

【 授权许可】

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