Metátese de olefinas aplicada ao fechamento de anéis: uma ferramenta poderosa para a síntese de macrociclos naturais

Química Nova

Anderson Rouge Dos Santos²  Carlos Roland Kaiser²  Jean-pierre Férézou¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Química Rio de Janeiro RJ ,Brasil

关键词: macrocycles;    olefins;    ring-closing metathesis;   

DOI  :  10.1590/S0100-40422008000300033

来源: SciELO

【 摘 要 】

For a quarter of a century, metathesis has become indispensable for the synthesis of natural and non-natural products, particularly of biologically active compounds. This review illustrates through a maximum of appropriate examples the power and the versatility of the metathesis ring-closure (RCM) reaction as a key ring-closure methodology for the synthesis of natural macrocycles. Its high functional group compatibility as well as the possibility of further transformations makes this reaction a powerful tool in the cases where the structural framework and function requirements are difficult to meet.

【 授权许可】

CC BY-NC   
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