Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate

Química Nova

Breno De Carvalho E Silva¹  Lígia Maria Moreira De Campos¹  Gerson Antônio Pianetti¹ 

[1] ,Universidade Federal de Minas Gerais Faculdade de Farmácia Departamento de Produtos FarmacêuticosBelo Horizonte MG

关键词: indinavir sulfate;    titration;    sulfate ion content;   

DOI  :  10.1590/S0100-40422005000100011

来源: SciELO

【 摘 要 】

A simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric method for sulfate ion quantitation using 0.1 mol L-1 lead perchlorate as titrant. Both methods were validated concerning linearity, precision and accuracy, yielding good results. The sulfate ion content found by the two validated methods was compared by the statistical t-student test, indicating that there was no statistically significant difference between the methods.

【 授权许可】

CC BY-NC   
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