Reações de ortometalacão em piridinas

Química Nova

Marcus .v. N. De Souza¹  Mauro V. De Almeida¹ 

[1] ,Universidade Federal de Juiz de Fora Departamento de Química Juiz de Fora MG

关键词: ortho-metalation;    directed metallation group;    heteroaromatic compounds;   

DOI  :  10.1590/S0100-40422002000100016

来源: SciELO

【 摘 要 】

In this paper we describe a powerful methodology for the regiospecific construction of polysubstituted aromatic and heteroaromatic compounds. The DoM reaction (direct ortho-metalation) comprises the deprotonation in position ortho of a aromatic or heteroaromatic containing DMG (directed metalation group) by strong bases, normally an alkyllithium reagent, leading to an ortho-lithiated species. These species, upon treatment with electrophilic reagents, gives 1,2 disubstituted products.

【 授权许可】

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