Pharmacotherapy and analysis of gaseous mediators in hypertensive patients

Revista da Escola de Enfermagem da USP

Letícia Palota Eid¹  Renato Nery Soriano¹  Marcelo Eduardo Batalhão¹  Lais Palotta Balderrama¹  Evelin Capellari Carnio¹ 

关键词: Hypertension;    Nitric Oxide;    Hydrogen Sulfide;    Antihypertensive Agents;    Hipertensión;    Óxido Nítrico;    Sulfuro de Hidrógeno;    Antihipertensivos;    Hipertensão;    Óxido Nítrico;    Sulfeto de Hidrogênio;    Anti-Hipertensivos;   

DOI  :  10.1590/S0080-623420150000100009

来源: SciELO

【 摘 要 】

OBJECTIVE To evaluate the effect of using antihypertensive classes of drugs of the calcium channel antagonists and inhibitors of angiotensin-converting enzyme in plasma concentrations of hydrogen sulfide and nitric oxide in patients with hypertension. METHODS Cross-sectional study with quantitative approach conducted with hypertensive patients in use of antihypertensive classes of drugs: angiotensin-converting enzyme inhibitors or calcium channel antagonists. RESULTS It was found that the concentration of plasma nitric oxide was significantly higher in hypertensive patients that were in use of angiotensin-converting enzyme inhibitors (p<0.03) and the hydrogen sulphide concentration was significantly higher in hypertensive plasma in use of calcium channel antagonists (p<0.002). CONCLUSION The findings suggest that these medications have as additional action mechanism the improvement of endothelial dysfunction by elevate plasma levels of vasodilatory substances.

【 授权许可】

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