Interleukin-10 rs1800896 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock

Memórias do Instituto Oswaldo Cruz

Cristina Padre Cardoso¹  Argenil José De Assis De Oliveira¹  Fernando Antônio Botoni¹  Isabela Cristina Porto Rezende¹  Jose Carlos Alves-filho¹  Fernando De Queiroz Cunha¹  Juliana De Assis Silva Gomes Estanislau¹  Luiz Alexandre Viana Magno¹  Fabricio Rios-santos¹ 

关键词: sepsis;    septic shock;    biomarkers;    polymorphisms;    inflammation;    intensive care unit;   

DOI  :  10.1590/0074-02760150003

来源: SciELO

【 摘 要 】

Despite major improvements in its treatment and diagnosis, sepsis is still a leading cause of death and admittance to the intensive care unit (ICU). Failure to identify patients at high risk of developing septic shock contributes to an increase in the sepsis burden and rapid molecular tests are currently the most promising avenue to aid in patient risk determination and therapeutic anticipation. The primary goal of this study was to evaluate the genetic susceptibility that affects sepsis outcome in 72 sepsis patients admitted to the ICU. Seven polymorphisms were genotyped in key inflammatory response genes in sepsis, including tumour necrosis factor-α,interlelukin (IL)-1β, IL-10,IL-8, Toll-like receptor 4, CXCR1and CXCR2. The primary finding showed that patients who were homozygous for the major A allele in IL-10rs1800896 had almost five times higher chance to develop septic shock compared to heterozygotes. Similarly, selected clinical features and CXCR2rs1126579 single nucleotide polymorphisms modulated septic shock susceptibility without affecting survival. These data support the hypothesis that molecular testing has clinical usefulness to improve sepsis prognostic models. Therefore, enrichment of the ICU portfolio by including these biomarkers will aid in the early identification of sepsis patients who may develop septic shock.

【 授权许可】

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