Prevalence and genetic characterisation of HTLV-1 and 2 dual infections in patients with pulmonary tuberculosis in Central-West Brazil

Memórias do Instituto Oswaldo Cruz

Aline Garcia Kozlowski¹  Megmar Aparecida Dos Santos Carneiro¹  Márcia Alves Dias De Matos¹  Sheila Araújo Teles¹  João Alves Araújo Filho¹  Koko Otsuki¹  Ana Carolina Paulo Vicente¹  Regina Maria Bringel Martins¹ 

关键词: HTLV-1;    HTLV-2;    tuberculosis;    prevalence;   

DOI  :  10.1590/0074-0276130230

来源: SciELO

【 摘 要 】

Human T-cell lymphotropic virus (HTLV) may impact the clinical course of tuberculosis (TB). Both infections are highly endemic in Brazil. The aim of this study was to assess the prevalence of HTLV-1/2 in TB patients in Central-West Brazil and to perform a genetic characterisation of the respective isolates. Of the 402 patients, six (1.49%) were positive for anti-HTLV and five (1.24%; 95% confidence interval: 0.46-3.05) were infected with HTLV-1/2. Genetic characterisation demonstrated that the four HTLV-1 isolates belonged to the Transcontinental subgroup A of the Cosmopolitan subtype a and that the HTLV-2 isolate belonged to subtype a (HTLV-2a/c). The prevalence of HTLV infection observed in this study is higher than that observed in local blood donors and the HTLV-1 and 2 subtypes identified are consistent with those circulating in Brazil.

【 授权许可】

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