Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges

Memórias do Instituto Oswaldo Cruz

Christopher Steven Eickhoff¹  Brian Anthony Dunn¹  Nicole Lea Sullivan¹  Daniel Fredric Hoft¹ 

关键词: Trypanosoma cruzi;    mucosal immunity;    Chagas disease;    animal disease models;    infection control;   

DOI  :  10.1590/S0074-02762013000400018

来源: SciELO

【 摘 要 】

Trypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunctival infections result in obvious local physical signs. In this study we compared the infectivity of T. cruzi IMT in mice after cutaneous and oral contaminative challenges simulating natural infections. The 50% infective dose (ID50) for oral challenge was 100 fold lower than the ID50for cutaneous challenge, indicating that oral mucosal transmission is more efficient than cutaneous transmission.

【 授权许可】

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