Occult hepatitis B virus infection among injecting drug users in the Central-West Region of Brazil

Memórias do Instituto Oswaldo Cruz

Marcia Alves Dias De Matos¹  Renata Carneiro Ferreira¹  Fabiana Perez Rodrigues¹  Tamiris Augusto Marinho¹  Carmen Luci Rodrigues Lopes¹  Antonia Carlos Magalhaes Novais¹  Ana Rita Coimbra Motta-castro¹  Sheila Araujo Teles¹  Francisco Jose Dutra Souto¹  Regina Maria Bringel Martins¹ 

关键词: hepatitis B virus;    occult infection;    genotypes;   

DOI  :  10.1590/S0074-02762013000300019

来源: SciELO

【 摘 要 】

The prevalence of occult hepatitis B virus (HBV) infection was investigated in 149 hepatitis B surface antigen (HBsAg) negative injecting drug users (IDUs) in the Central-West Region of Brazil. Of these individuals, 19 were positive for HBV DNA, resulting in an occult HBV infection prevalence of 12.7% (19/149); six of these 19 individuals had anti-HBV core and/or anti-HBV surface antibodies and 13 were negative for HBV markers. All IDUs with occult hepatitis B reported sexual and/or parenteral risk behaviours. All HBV DNA-positive samples were successfully genotyped. Genotype D was the most common (17/19), followed by genotype A (2/19). These findings reveal a high prevalence of occult HBV infection and the predominance of genotype D among IDUs in Brazil's Central-West Region.

【 授权许可】

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