Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital

Memórias do Instituto Oswaldo Cruz

Graziella Hanna Pereira²  Doroti O Garcia¹  Marcelo Mostardeiro²  Karina Svn Fanti²  Anna S Levin¹ 

[1] ,Hospital Brigadeiro Departamento de Controle de Infecção São Paulo SP ,Brasil

关键词: carbapenem-resistant K. pneumoniae;    nosocomial outbreak;    polymyxin resistance;   

DOI  :  10.1590/S0074-02762013000100019

来源: SciELO

【 摘 要 】

This study describes a carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the blaKPC gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 CRKP infections; PFGE revealed five genotypes: genotype A in five (15%), B in 18 (55%), C in eight (24%) and two unique profiles. Genotype B was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of São Paulo. Sixteen (48%) patients died. Seven isolates (21%) were resistant to polymyxin B and 45% were resistant to tigecycline and amikacin.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License