The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi

Memórias do Instituto Oswaldo Cruz

Leticia Pérez-díaz²  Alejandro Correa¹  Mariana P Moretão¹  Samuel Goldenberg¹  Bruno Dallagiovanna¹  Beatriz Garat² 

[1] ,Facultad de Ciencias Laboratorio de Interacciones Moleculares Montevideo,Uruguay

关键词: differentiation;    metacyclogenesis;    amastigogenesis;   

DOI  :  10.1590/S0074-02762012000800021

来源: SciELO

【 摘 要 】

To characterise the trypanosomatid-exclusive RNA-binding protein TcRBP19, we analysed the phenotypic changes caused by its overexpression. Although no evident changes were observed when TcRBP19 was ectopically expressed in epimastigotes, the metacyclogenesis process was affected. Notably, TcRBP19 overexpression also led to a decrease in the number of infected mammalian cells. These findings suggest that TcRBP19 may be involved in the life cycle progression of the Trypanosoma cruzi parasite.

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