The impact of highly active antiretroviral therapy on the survival of vertically HIV-infected children and adolescents in Belo Horizonte, Brazil

Memórias do Instituto Oswaldo Cruz

Claudete Aparecida Araújo Cardoso¹  Jorge A Pinto¹  Talitah Michel Sanchez Candiani¹  Inácio Roberto De Carvalho¹  Renato Moreira Linhares¹  Eugênio Marcos Andrade Goulart¹ 

[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Belo Horizonte MG ,Brasil

关键词: HIV;    children and adolescents;    historic cohort;    survival;    HAART;   

DOI  :  10.1590/S0074-02762012000400014

来源: SciELO

【 摘 要 】

The use of highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV)-infected patients has reduced the number of acquired immune deficiency syndrome-related deaths worldwide. This study assessed the impact of HAART on the survival and death rates of vertically HIV-infected children and adolescents in Belo Horizonte, Brazil. Data were obtained from a historic cohort of vertically HIV-infected children and adolescents aged zero-19 years old who were admitted from March 1989-December 2004 and were followed until June 2006. Patients who used HAART were included if they were treated for at least 12 weeks. Of 359 patients, 320 patients met the inclusion criteria. The overall mortality rate was 9.7% [31/320; 95% confidence interval (CI): 6.0-13%]. The median survival for the non-HAART and HAART groups was 31.5 and 55.9 months, respectively (log rank = 22.11, p < 0.0001). In the multivariate analysis, the statistically significant variables were HAART and the weight-for-age Z score < -2, with HAART constituting a protective factor [relative risk (RR): 0.13; CI 95%: 0.05-0.33] and malnutrition constituting a risk factor (RR: 3.44; CI 95%: 1.60-7.40) for death. The incidence of death was 5.1/100 person-years in the non-HAART group and 0.8/100 person-years in the HAART group (p < 0.0001).

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