Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV

Memórias do Instituto Oswaldo Cruz

Daisy Maria Machado²  Maria Cristina Fink²  Cláudio Sérgio Pannuti²  Regina Célia De Menezes Succi¹  Alessandra Aparecida Machado²  Fabiana Bononi Do Carmo¹  Aída De Fátima Barbosa Gouvêa¹  Paulo Roberto Urbano²  Suenia Vasconcelos Beltrão¹  Isabel Cristina Lopes Dos Santos¹  Clarisse Martins Machado¹ 

[1],Universidade de São Paulo Instituto de Medicina Tropical de São Paulo Laboratório de VirologiaSão Paulo SP ,Brasil

关键词: HIV-1;    child;    adolescent;    JC virus;    BK virus;    urine;   

DOI  :  10.1590/S0074-02762011000800006

来源: SciELO

【 摘 要 】

The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License