Chikungunya virus outbreak in Kerala, India, 2007: a seroprevalence study

Memórias do Instituto Oswaldo Cruz

Narendran Pradeep Kumar²  Abidha Suresh²  Perumal Vanamail¹  Shanmugavelu Sabesan¹  Kalianna Gounder Krishnamoorthy¹  Jacob Mathew¹  Varakilparambil Thomas Jose¹  Purushothaman Jambulingam² 

[1] ,Vector Control Research Centre Field StationKerala,India

关键词: Chikungunya virus;    serosurveillance;    India;    rubber plantation;    Kerala;    Aedes albopictus;   

DOI  :  10.1590/S0074-02762011000800003

来源: SciELO

【 摘 要 】

India was affected by a major outbreak of chikungunya fever caused by Chikungunya virus (CHIKV) during 2006-2007. Kerala was the worst affected state during 2007 with a contribution of 55.8% suspected cases in the country. However, except for clinically reported case records, no systematic information is available on infection status of CHIKV in the region. Hence, we carried out a post-epidemic survey to estimate seroprevalence status [immunoglobulin G (IgG)] in the community using commercially available indirect immunofluorescence test. This methodology had been reported to be highly specific and sensitive for CHIKV infection. The study area selected was the worst affected mid-highlands region of Kerala which harbour vast area of rubber plantations. The study evidenced 68% of the population to be seropositive for CHIKV IgG. Males were found more affected than females (χ2 = 9.86; p = 0.002). Among males, prevalence was significantly higher in the age classes 21-30 (χ2 = 5.46; p = 0.019) and 31-40 (χ2 = 5.84; p = 0.016) years. This may be due to high occupational risk of the male population engaged in plantation activities exposed to infective bites of Aedes albopictus. The current study provides an insight into the magnitude of CHIKV outbreak in Kerala.

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