High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters

Memórias do Instituto Oswaldo Cruz

Ana Lúcia Souza Antunes¹  Jéssica Weis Bonfanti¹  Leandro Reus Rodrigues Perez¹  Camille Cattani Ferreira Pinto¹  Ana Lúcia Peixoto De Freitas¹  Alexandre José Macedo¹  Afonso Luis Barth¹ 

[1] ,Faculdade de Farmácia

关键词: biofilm;    vancomycin;    Staphylococcus spp;   

DOI  :  10.1590/S0074-02762011000100008

来源: SciELO

【 摘 要 】

Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection.

【 授权许可】

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