Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation - A Review

Memórias do Instituto Oswaldo Cruz

Cristiana S De Macedo²  Ralph T Schwarz¹  Adriane R Todeschini²  Jose O Previato²  Lucia Mendonça-previato² 

[1] ,Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde Instituto de Biofísica Carlos Chagas FilhoRio de Janeiro RJ ,Brasil

关键词: glycoproteins;    glycosylation;    N-glycan;    O-glycan;    Plasmodium;   

DOI  :  10.1590/S0074-02762010000800001

来源: SciELO

【 摘 要 】

Human malignant malaria is caused by Plasmodium falciparum and accounts for almost 900,000 deaths per year, the majority of which are children and pregnant women in developing countries. There has been significant effort to understand the biology of P. falciparum and its interactions with the host. However, these studies are hindered because several aspects of parasite biology remain controversial, such as N- and O-glycosylation. This review describes work that has been done to elucidate protein glycosylation in P. falciparum and it focuses on describing biochemical evidence for N- and O-glycosylation. Although there has been significant work in this field, these aspects of parasite biochemistry need to be explored further.

【 授权许可】

CC BY   
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