Effectiveness and safety of isoniazid chemoprophylaxis for HIV-1 infected patients from Rio de Janeiro

Memórias do Instituto Oswaldo Cruz

Claudia Teresa Vieira De Souza¹  Yara Hahr Marques Hökerberg¹  Sandro Javier Bedoya Pacheco¹  Valéria Cavalcanti Rolla²  Sonia Regina Lambert Passos² 

[1] ,Fundação Oswaldo Cruz Instituto Evandro Chagas Laboratório de Epidemiologia Clínica

关键词: tuberculosis;    chemoprophylaxis;    isoniazid;    HIV-1;    clinical trial;    treatment outcome;   

DOI  :  10.1590/S0074-02762009000300011

来源: SciELO

【 摘 要 】

The clinical and epidemiological characteristics, adverse events, treatment adherence and effectiveness of isoniazid chemoprophylaxis were analyzed in a cohort of 138 tuberculosis/HIV-coinfected patients. An open, non-randomized, pragmatic prophylactic trial was conducted on adult patients with a normal chest X-ray and positive tuberculin skin test (> 5 mm) who received isoniazid chemoprophylaxis (300 mg/day) for six months. The mean of follow up was 2.8 years (SD 1.3). Adherence to chemoprophylaxis was 87.7% (121/138). Only one patient presented tuberculosis after the end of chemoprophylaxis, corresponding to 0.3 cases per 100 persons per year. The relative risk of some adverse effects was 4.6 times higher (95% CI: 1.9-11.5) in patients with positive anti-HCV serology (4/9, 44.4%) compared to those with negative serology (12/129, 9.6%) (p = 0.002). This study provides evidence regarding the effectiveness and safety of a short and self-administered isoniazid regimen. We recommend the implementation of this routine by health service practitioners.

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