In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus

Memórias do Instituto Oswaldo Cruz

Márcia Cristina Carriel-gomes²  Jadel Müller Kratz²  Margherita Anna Barracco¹  Evelyne Bachére¹  Célia Regina Monte Barardi¹  Cláudia Maria Oliveira Simões² 

[1] ,Universidade Federal de Santa Catarina Departamento de Ciências Farmacêuticas Laboratório de Virologia Aplicada

关键词: antimicrobial peptides;    antiviral activity;    herpesvirus;    adenovirus;    rotavirus;   

DOI  :  10.1590/S0074-02762007005000028

来源: SciELO

【 摘 要 】

Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.

【 授权许可】

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