Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Memórias do Instituto Oswaldo Cruz

Akintunde Sowunmi¹  Grace O Gbotosho¹  Christian T Happi¹  Ahmed A Adedeji¹  Olayinka M Bolaji¹  Fatai A Fehintola¹  Babasola A Fateye¹  Ayoade Mj Oduola¹ 

[1] ,University of Ibadan Institute for Medical Research and Training Department of Pharmacology and TherapeuticsIbadan,Nigeria

关键词: amodiaquine;    chlorpheniramine;    resistance reversal;    malaria;    children;   

DOI  :  10.1590/S0074-02762007005000038

来源: SciELO

【 摘 要 】

Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vitro and enhances its efficacy in vivo, in five children who failed CQ and/or AQ treatment, and who were subsequently retreated and cured with a combination of AQ plus CP, despite the fact that parasites infecting the children harboured mutant pfcrtT76 and pfmdr1Y86 alleles associated with AQ resistance. This suggests a potential clinical appliation of the reversal phenomenon.

【 授权许可】

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