Memórias do Instituto Oswaldo Cruz | |
Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo | |
Akintunde Sowunmi1  Grace O Gbotosho1  Christian T Happi1  Ahmed A Adedeji1  Olayinka M Bolaji1  Fatai A Fehintola1  Babasola A Fateye1  Ayoade Mj Oduola1  | |
[1] ,University of Ibadan Institute for Medical Research and Training Department of Pharmacology and TherapeuticsIbadan,Nigeria | |
关键词: amodiaquine; chlorpheniramine; resistance reversal; malaria; children; | |
DOI : 10.1590/S0074-02762007005000038 | |
来源: SciELO | |
【 摘 要 】
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vitro and enhances its efficacy in vivo, in five children who failed CQ and/or AQ treatment, and who were subsequently retreated and cured with a combination of AQ plus CP, despite the fact that parasites infecting the children harboured mutant pfcrtT76 and pfmdr1Y86 alleles associated with AQ resistance. This suggests a potential clinical appliation of the reversal phenomenon.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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