In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants

Memórias do Instituto Oswaldo Cruz

Valter F De Andrade-neto²  Adrian M Pohlit¹  Ana Cristina S Pinto¹  Ellen Cristina C Silva¹  Karla L Nogueira¹  Márcia Rs Melo¹  Marycleuma C Henrique²  Rodrigo Cn Amorim²  Luis Francisco R Silva¹  Mônica Rf Costa¹  Rita Cs Nunomura¹  Sergio M Nunomura¹  Wilson D Alecrim¹  M Das Graças C Alecrim¹  F Célio M Chaves¹  Pedro Paulo R Vieira¹ 

[1] ,Universidade Federal do Rio Grande do Norte Laboratório de Biologia da Malária e Toxoplasmose Natal RN ,Brasil

关键词: neosergeolide;    ellipticine;    aspidocarpine;    4-nerolidylcatechol;    Pothomorphe peltata;    Picrolemma sprucei;    Aspidosperma spp;   

DOI  :  10.1590/S0074-02762007000300016

来源: SciELO

【 摘 要 】

In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived.

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