Inflammatory effects of snake venom metalloproteinases

Memórias do Instituto Oswaldo Cruz

Catarina De Fátima Pereira Teixeira¹  Cristina Maria Fernandes¹  Juliana Pavan Zuliani¹  Silvia Fernanda Zamuner¹ 

[1] ,Instituto Butantan Laboratório de Farmacologia São Paulo SP ,Brasil

关键词: metalloproteinase;    snake venom;    inflammation;   

DOI  :  10.1590/S0074-02762005000900031

来源: SciELO

【 摘 要 】

Metalloproteinases are abundant enzymes in crotaline and viperine snake venoms. They are relevant in the pathophysiology of envenomation, being responsible for local and systemic hemorrhage frequently observed in the victims. Snake venom metalloproteinases (SVMP) are zinc-dependent enzymes of varying molecular weights having multidomain organization. Some SVMP comprise only the proteinase domain, whereas others also contain a disintegrin-like domain, cysteine-rich, and lectin domains. They have strong structural similarities with both mammalian matrix metalloproteinases (MMP) and members of ADAMs (a disintegrin and metalloproteinase) group. Besides hemorrhage, snake venom metalloproteinase induce local myonecrosis, skin damage, and inflammatory reaction in experimental models. Local inflammation is an important characteristic of snakebite envenomations inflicted by viperine and crotaline snake species. Thus, in the recent years there is a growing effort to understand the mechanisms responsible for SVMP-induced inflammatory reaction and the structural determinants of this effect. This short review focuses the inflammatory effects evoked by SVMP.

【 授权许可】

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