Seroprevalence of viral hepatitis in riverine communities from the Western Region of the Brazilian Amazon Basin

Memórias do Instituto Oswaldo Cruz

Vs De Paula²  Me Arruda¹  Cl Vitral¹  Amc Gaspar² 

[1] ,Instituto Oswaldo Cruz-Fiocruz Departamento de Virologia Rio de Janeiro RJ ,Brasil

关键词: hepatitis A;    hepatitis B;    hepatitis C;    hepatitis D;    hepatitis E;    Amazon Basin;    Brazil;   

DOI  :  10.1590/S0074-02762001000800016

来源: SciELO

【 摘 要 】

The western region of the Brazilian Amazon Basin has long been shown to be a highly endemic area for hepatitis B and hepatitis D viruses. Data concerning the prevalence of hepatitis C and E viruses in this region are still scarce. In this study we investigated the presence of hepatitis A, B, C, D and E viruses infection in communities that live along the Purus and Acre rivers in the states of Acre and Amazonas within the Amazon Basin. A total of 349 blood samples were collected and tested for hepatitis A-E serological markers (antibodies and/or antigens) using commercial enzyme linked immunosorbent assays. Anti-HCV positive sera were further assayed by an immunoblot. HBsAg positive sera were subtyped by immunodifusion. The overall prevalence for hepatitis A, B, C, and E were 93.7%, 66.1%, 1.7%, and 4%, respectively. A very high prevalence of delta hepatitis (66.6%) was found among HBsAg positive subjects. Hepatitis A, B and D viruses were shown to be largely disseminated in this population, while hepatitis C and E viruses infection presented low prevalence rates in this region. The analysis of risk factors for HBV infection demonstrated that transmission was closely associated with sexual activity.

【 授权许可】

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