Detection of circulant tumor necrosis factor-alpha , soluble tumor necrosis factor p75 and interferon-gamma in Brazilian patients with dengue fever and dengue hemorrhagic fever

Memórias do Instituto Oswaldo Cruz

Elzinandes La Braga²  Patrícia Moura¹  Luzia Mo Pinto²  Sonia Rn Ignácio²  Maria José C Oliveira¹  Marly T Cordeiro¹  Claire F Kubelka² 

[1] ,Instituto Oswaldo Cruz-Fiocruz Departamento de Virologia Rio de Janeiro RJ ,Brasil

关键词: dengue;    cytokines;    dengue hemorrhagic fever;   

DOI  :  10.1590/S0074-02762001000200015

来源: SciELO

【 摘 要 】

Pro-inflammatory cytokines are believed to play an important role in the pathogenesis of dengue infection. This study reports cytokine levels in a total of 54 patients examined in Recife, State of Pernambuco, Brazil. Five out of eight patients who had hemorrhagic manifestations presented tumor necrosis factor-alpha (TNF-alpha) levels in sera which were statistically higher than those recorded for controls. In contrast, only one out of 16 patients with mild manifestations had elevated TNF-alpha levels. The levels of interleukin-6 (IL), IL-1beta tested in 24 samples and IL-12 in 30 samples were not significantly increased. Interferon-g was present in 10 out of 30 patients with dengue. The data support the concept that the increased level of TNF-alpha is related to the severity of the disease. Soluble TNF receptor p75 was found in most patients but it is unlikely to be related to severity since it was found with an equivalent frequency and levels in 15 patients with dengue fever and another 15 with dengue hemorrhagic fever.

【 授权许可】

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