Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil

Memórias do Instituto Oswaldo Cruz

Luiz Rr Castello-branco¹  Maria Beatriz Ortigão-de-sampaio¹ 

[1] ,Instituto Oswaldo Cruz Departamento de Imunologia Laboratório de Imunologia ClínicaRio de Janeiro RJ ,Brasil

关键词: gastrointestinal immunology;    human immunodeficiency virus-1 infection;    nutrition;    mucosal immunology;   

DOI  :  10.1590/S0074-02762000000700028

来源: SciELO

【 摘 要 】

Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.

【 授权许可】

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