Frequency of specific anti-Toxoplasma gondii IgM, IgA and IgE in Colombian patients with acute and chronic ocular toxoplasmosis

Memórias do Instituto Oswaldo Cruz

Jorge Enrique Gómez-marín¹  Maria Teresa Montoya-de-londoño¹  Jhon Carlos Castaño-osorio¹  Fernando Alvarado Heine¹  Ana Maria Duque¹  Cathy Chemla²  Dominique Aubert²  Annie Bonhomme²  Jean Michel Pinon² 

[1] ,Université de Reims Champagne-ArdenneReims,France

关键词: toxoplasmosis;    human ocular toxoplasmosis;    IgG;    IgM;    IgA;    IgE;   

DOI  :  10.1590/S0074-02762000000100014

来源: SciELO

【 摘 要 】

We studied the frequency of specific anti-Toxoplasma IgM, IgA and IgE antibodies in serum of 28 immunocompetent Colombian patients, selected by ophthalmologists and with lesions that were compatible with ocular toxoplasmosis. Patients were classified in three groups: (i) group 1 consisted of ten patients with a first episode; (ii) group 2, with seven patients with a recurrence and (iii) group 3, consisted of eleven patients with chronic chorioretinal lesion without uveitis. We found that 10/28 (35%) of Colombian patients with ocular toxoplasmosis possessed at least one serological marker for Toxoplasma infection different from IgG. In group 1 (first episode), we found simultaneous presence of specific IgM plus IgA plus IgE in 1/10 (10%). In group 2 (recurrences) in 1/7 (14%) we found IgM and IgA test positives and in 1/7 (14%) we found IgM and IgE tests positives. In group 3 (toxoplasmic chorioretinal scar) the IgA serological test was positive in 2/11 (18%). These results show that serum IgM or IgA or IgE can be present during recurrences.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License