Circulating Antigens Levels in Different Clinical Forms of the Schistosoma mansoni Infection

Memórias do Instituto Oswaldo Cruz

Yerkes Pereira E Silva²  Evan Secor¹  Marcela Orsine Andrade²  Naftale Katz²  Ana Rabello² 

[1] ,Centro de Pesquisas René Rachou-Fiocruz

关键词: Schistosoma mansoni;    circulating antigens;    diagnosis;    ELISA;   

DOI  :  10.1590/S0074-02761999000100017

来源: SciELO

【 摘 要 】

With the aim to evaluate the circulating cathodic antigen (CCA) levels in relation to the different clinical phases of Schistosoma sp. infection a sandwich ELISA using monoclonal antibody 5H11 was performed. The sera of three groups of 25 Brazilian patients with acute, intestinal and hepatosplenic forms of S. mansoni infection were tested and compared to a non-infected control group. Patients and control groups were matched for age and sex and the number of eggs per gram of feces was equally distributed among the three patient groups. Sensitivity of 100%, 72%, 52% of the assay was observed for the intestinal, hepatosplenic and acute toxemic groups respectively. The specificity was 100%. Intestinal and hepatosplenic groups presented CCA levels significantly higher in comparison to those observed for acute patients (F-ratio = 2,524; p = 0.000 and F-ratio = 6,314; p = 0.015 respectively). There was no significant difference of CCA serum levels between hepatosplenic and intestinal groups (F-ratio = 1,026; p = 0.316).

【 授权许可】

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