Immune Dysfunction and the Pathogenesis of AIDS-associated non-Hodgkin's Lymphoma

Memórias do Instituto Oswaldo Cruz

Otoniel Martínez-maza¹  Daniel Widney¹  Meta Van Der Meijden¹  Reba Knox¹  Angela Echeverri¹  Elizabeth C Breen¹  Larry Magpantay¹  Steven A Miles¹ 

[1] ,UCLA School of Medicine

关键词: B lymphocytes;    HIV;    AIDS;    lymphoma;    interleukin 6;    HHV8;   

DOI  :  10.1590/S0074-02761998000300019

来源: SciELO

【 摘 要 】

Much has been learned about how HIV-induced immune dysfunction contributes to B cell hyperactivation, and potentially, to the pathogenesis of AIDS-lymphoma. However, further studies are needed to fully understand how HIV infection and immune dysfunction promote B cell hyperactivation and the development/growth of AIDS-lymphoma. In particular, studies are needed to define the role of HHV8 vIL6, IL6 receptor-expression, and lymphocyte surface stimulatory molecules, in promoting B cell hyperactivation or lymphoma cell growth.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License