Immunological profiles of patients from endemic areas infected with Schistosoma mansoni

Memórias do Instituto Oswaldo Cruz

Giovanni Gazzinelli²  Iramaya R. C. Viana²  Lilian M. G. Bahia-oliveira²  Alda Maria S. Silveira²  Claudia Carvalho Queiroz²  Omar Dos Santos Carvalho²  Cristiano L. Massara²  Lucia A. O. Fraga²  Daniel G. Colley¹  Rodrigo Correa Oliveira² 

[1] ,FIOCRUZ Centro de Pesquisas René Rachou Belo Horizonte,Brasil

关键词: schistosomiasis mansoni;    clinical immunology;   

DOI  :  10.1590/S0074-02761992000800020

来源: SciELO

【 摘 要 】

Crude extracts of eggs (SEA) adult worms (SWAP) or cercariae (Cerc) have been used to stimulate Peripheral Blood Mononuclear cells (PBMC) and have provided rather distinct profiles of responses in different types of patients. In genenral it is clear that patients with early infections respond strongly to SEA while response to SWAP are developed more slowly. As infection progresses into the more chronic phases, a general pattern is seen whic leads to lower anti-SEA proliferative responses in the face of higher responses to SWAP and variable anti-cerc responsiveness. Cured not re-exposed patients express very high levels of anti-SEA proliferation. It has recently been seen that those individuals who live in endemic areas and have continued water contact, but are reapeatedly stool-negative (who are presumed to have self-cured or be putatively resistant; endemic normals) are strongly responsive to antigenic extracts, particularly to SEA. Furthermore, our results show that endemic normal individuals have significantly higher IFN gamma production upon PBMC stimulation with schistosome antigens than infected individuals. With the emergence of more studies it is becoming apparent that both the intensity and the prevalence of a given area may influence or shape the general responsiveness of the population under study.

【 授权许可】

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