The role of cytokines in the pathogenesis of hepatic granulomatous disease in Schistosoma mansoni infected mice

Memórias do Instituto Oswaldo Cruz

Allen W. Cheever¹  Yuhui Xu¹  Jane G. Macedonia¹  Teresa Cox¹  Sara Hieny¹  Alan Sher¹ 

[1] ,NIH NIAID Laboratory of Parasitic DiseasesBethesda,USA

关键词: Schistosoma mansoni;    cytokines;    pathogenesis;    IL-2;    IL-4;    IL-5;    IFN-y;   

DOI  :  10.1590/S0074-02761992000800011

来源: SciELO

【 摘 要 】

Cytokines are important in the cell-mediated response to Schistosoma mansoni eggs. We have found that Th2 cytokine responses (e.G. IL-4 and IL-5) are argumented after egg laying begins while the response (IL-2 and IFN-*) are down regulated in S. mansoni infected mice. Treatment of mice with anti-IL-5 monoclonal antibodies (Mab) suppressed the eosinophil response almost completley but did not affect granuloma size and slightly increased hepatic fibrosis. Anti-IL-4 treatment abolished IgE responses in infected mice and decreased hepatic fibrosis slightly. Anti-IFN-* treatment had no effect on hepatic pathology. Anti-IL-2 treatment decreased granuloma size significantly and decreased hepatic fibrosis markedly. Anti-IL-2 treatment dramatically decreased IL-5 secretion by splenic cells in vitro and decreased peripheral blood and tissue eosinophilia. In contrast IL-4 secretion was unaffected and serum IgE was normal or increased. IL-2 and IFN-* secretion by splenic cells of treated mice were slightly but not significantly increased suggesting that anti-IL-2 treatment affecting Th2 rather than Th1 responses.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License