Schizotrypanids: the occurence of dermatitis in immunodeficiency animals infected with Trypanosoma cruzi

Memórias do Instituto Oswaldo Cruz

Sylvio Celso Gonçalves Da Costa¹  Kátia Da Silva Calabrese¹ 

[1] ,Instituto Oswaldo Cruz Departamento de Protozoologia Laboratório de ImunomodulaçãoRio de Janeiro,Brasil

关键词: Trypanosoma cruzi;    dermatitis;    immunodeficience;    schizotrypanids;    nude mice;   

DOI  :  10.1590/S0074-02761992000500015

来源: SciELO

【 摘 要 】

Congenitally athymic nude Balb/c (nu/nu) and their phenothypically normal adult and neonate littermates (nu/+), the C3H/HeN as well, were intraperitoneally infected with two strains (Y or CL) of Trypanossoma cruzi. The nude mice and the neonates developed a severe parasitaemia, the susceptible C3H/HeN also presented high level and adult Balb/c mice presented parasitaemia similar to that observed in outbred mice. Erythematous skin lesions were observed initially in infected athymic nude and neonates, being charactherized by nests of amastigotes in the dermis; in C3H/HeN infected mice no nest of parasite was observed but a low-grade inflammatory reaction was seen. In adult Balb/c or OF1 outbred mice nest was found but discreet inflammatory reaction was observed in severe infections.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License