Trypanosomatidae codon usage and GC distribution

Memórias do Instituto Oswaldo Cruz

Guilhermina Alonso¹  Palmira Guevara¹  Jose L. Ramirez¹ 

[1] ,Universidad Central de Venezuela Centro de Biología Celular Caracas,Venezuela

关键词: Trypanosomatidae;    codon usage;    mutational pressure;    GC content;   

DOI  :  10.1590/S0074-02761992000400009

来源: SciELO

【 摘 要 】

A study od Typanosomatidae GC distribution and codon usage is presented. The codon usage patterns in coincidence with the phylogenetical data are similar in Crithidia and Leishmania, whereas they are more divergent in Trypanosoma brucei and T. cruzi. The analyisis of the GC mutational pressure in these organisms reveals that T. brucei, and to a lesser extent T. cruzi, have envolved towards a more balanced use of all bases, whereas Leishmania and Crithidia retain features of a primeval genetic apparatus. Tables with approximated GC mutational pressure in homologous genes, and codon usage in Trypanosomatidae are presented.

【 授权许可】

CC BY   
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