Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents

Memórias do Instituto Oswaldo Cruz

J. M. Barbosa Filho²  M. F. Agra²  R. A. G. Oliveira²  M. Q. Paulo²  G. Trolin²  E. V. L. Cunha²  J. R. Ataide²  J. Bhattacharyya¹ 

[1] ,Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica João Pessoa,Brasil

关键词: soladine;    steroidal hormones;    Solanum;    alkaloid;   

DOI  :  10.1590/S0074-02761991000600043

来源: SciELO

【 摘 要 】

A systematic search for solasodine, an important staring material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliforum and Solanum sp. were found to contain significant amounts of solasodine. The root bark of S. paludosum which showe durare like activity yelded tomatidenol and another yet unidentified alkaloid responsible for the biological activity. The fruits of S. asperum yelded a new spirosolane alkaloid, solaparnaine. The stem bark of S. pseudo-quina showed convulsive and exitatory activity from which (25S)-isosolafloridine was identified as the active principle. In addition, the latter alkaloid was also found to show antimicrobial activity.

【 授权许可】

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