Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages

Memórias do Instituto Oswaldo Cruz

Eliane Lages-silva²  Leny S. Filardi¹  Zigman Brener¹ 

[1] ,Faculdade de Medicina do Triângulo MineiroUberaba,Brasil

关键词: Trypanosoma cruzi;    host treatment;    phagocytosis;    mouse;    macrophages;   

DOI  :  10.1590/S0074-02761990000400003

来源: SciELO

【 摘 要 】

Single doses of drugs active aginst Trypanosoma cruzi (megazol, nifurtimox and benznidazole) induce a rapid clearence of the blood parasites in experimentally infected mice. Furthermore, the in vitro phagocytosis and intracellular destruction by mouse peritoneal macrophage of blood forms collected from the treatment animals is strongly enhanced as compared with parasites from untreated controls. The uptake of the blood forms by macrophages is significantly higher with megazol than with benznidazole and nifurtimox, a finding that concurs with data showing that megazol is also the most active compound in the living host. The possibility that macrophages participate in a synergic effect between the host immune response and chemotherapeutic effect is discussed.

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