Memórias do Instituto Oswaldo Cruz | |
Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages | |
Eliane Lages-silva2  Leny S. Filardi1  Zigman Brener1  | |
[1] ,Faculdade de Medicina do Triângulo MineiroUberaba,Brasil | |
关键词: Trypanosoma cruzi; host treatment; phagocytosis; mouse; macrophages; | |
DOI : 10.1590/S0074-02761990000400003 | |
来源: SciELO | |
【 摘 要 】
Single doses of drugs active aginst Trypanosoma cruzi (megazol, nifurtimox and benznidazole) induce a rapid clearence of the blood parasites in experimentally infected mice. Furthermore, the in vitro phagocytosis and intracellular destruction by mouse peritoneal macrophage of blood forms collected from the treatment animals is strongly enhanced as compared with parasites from untreated controls. The uptake of the blood forms by macrophages is significantly higher with megazol than with benznidazole and nifurtimox, a finding that concurs with data showing that megazol is also the most active compound in the living host. The possibility that macrophages participate in a synergic effect between the host immune response and chemotherapeutic effect is discussed.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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