Selective serotonin-reuptake inhibitor and norepinephrine dopamine reuptake inhibitor antidepressants do not affect natural killer cell activity in vitro

Jornal Brasileiro de Psiquiatria

Gabriel J. Chittó Gauer²  Vivian M. Rumjanek¹  Sebastião Francisco Costa¹  Ramiro Ronchetti²  Rachel Rubin Da Silva²  Leonardo M. Da Silva² 

[1] ,Pontifícia Universidade Católica do Rio Grande do Sul

关键词: Natural killer activity;    antidepressants;    immune system;    psychoimmunology;    psychopharmacology;    drug toxicity;    Atividade natural killer;    antidepressivos;    sistema imune;    psicoimunologia;    psicofarmacologia;    toxicidade medicamentosa;   

DOI  :  10.1590/S0047-20852009000100007

来源: SciELO

【 摘 要 】

OBJECTIVE: This study aims to evaluate the citotoxic activity of two commonly used anti-depressants: paroxetine and bupropion. We also evaluated the in vitro natural killer activity (NKA) after incubating the blood samples with the antidepressants. METHODS: Peripheral blood samples from 15 healthy volunteers were collected and the mononuclear cells (PBMCs) were isolated and incubated for 24h with (or without = control cells) paroxetine and bupropion, in concentrations of 30, 100 and 1000 ng/ml. After the incubation period in both groups, the amount of dead cells was calculated using trypam blue technique. NKA was evaluated using the classic51Cr release assay. CONCLUSIONS: PBMCs dead cells occurred in both groups and in proportion to all pharmacological concentrations. Nevertheless, the NKA was not affected, even with the reduction in the number of effective cells.

【 授权许可】

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