Bioactive dihydroxyfuranonaphthoquinones from the bark of Tabebuia incana A.H. Gentry (Bignoniaceae) and HPLC analysis of commercial pau d'arco and certified T.incana bark infusions

Acta Amazonica

Sabrina Kelly Reis De Morais²  Suniá Gomes Silva²  Cíntia Nicácio Portela¹  Sergio Massayoshi Nunomura¹  Etienne Louis Jacques Quignard¹  Adrian Martin Pohlit¹ 

[1] ,Universidade Federal do Amazonas Instituto de Ciências Exatas Manaus Amazonas

关键词: Artemia franciscana Leach;    5-hydroxy-2-(1-hydroxyethyl)naphtho[2;    3-b]furan-4;    Artemia franciscana Leach;    5-hydroxy-2-(1-hydroxyethyl)naphtho[2;    3-b]furan-4;   

DOI  :  10.1590/S0044-59672007000100011

来源: SciELO

【 摘 要 】

Tabebuia incana A.H. Gentry (Bignoniaceae) is a tree from the Brazilian Amazon having medicinal uses and is one several Tabebuia spp. known as pau d'arco or palo de arco in this region. Fractionation of the bark ethanolic extract afforded a mixture of 5 and 8-hydroxy-2-(1-hydroxyethyl)naphtho[2,3-b]furan-4,9-diones (1 and 2, respectively) identified on the basis of nuclear magnetic resonance (NMR), infrared (IR) and mass (MS) spectra, whose in vitro antimalarial and antitumor activity have been shown previously. This is the first study on T. incana bark, and 2 are described in this species for the first time. Also, high performance liquid chromatography (HPLC) analysis of T. incana bark tea revealed the presence of the 1 + 2 mixture peak corresponding to a concentration in the range 10-6-10-5 M. The chromatograms of teas prepared from commercial pau d' arco and T. incana bark were also studied and the presence of the 1 + 2 peak has potential for quality control of commercial plant materials.

【 授权许可】

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