Schistosoma mansoni granuloma in late evolutive phase, in a case of tumoral form in man

Revista da Sociedade Brasileira de Medicina Tropical

Pedro Raso²  Leonardo Arruda Moraes Raso²  Ferdinan De Almeida Melo¹  Wagner Luiz Tafuri¹ 

[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Departamento de Anatomia Patológica e Medicina LegalBelo Horizonte MG

关键词: Schistosomiasis mansoni;    Granuloma;    Morphology;    Evolution and pseudotumor form;    Modulation of granuloma;    Equistossomose mansônica;    Granuloma;    Morfologia;    Evolução e forma pseudotumoral;    Modulação do granuloma;   

DOI  :  10.1590/S0037-86822012000500016

来源: SciELO

【 摘 要 】

INTRODUCTION: Authors describe human schistosomal granuloma in late chronic phase, from the morphological and evolutionary viewpoints. METHODS: The study was based on a histological analysis of two fragments obtained from a surgical biopsy of peritoneum and large intestine of a 42-year-old patient, with a pseudotumoral form mimicking a peritoneal carcinomatosis associated to the schistosomiasis hepatointestinal form. RESULTS: Two hundred and three granulomas were identified in the pseudotumor and 27 in the intestinal biopsy, with similar morphological features, most in the late chronic phase, in fibrotic healing. A new structural classification was suggested for granulomas: zone 1 (internal), 2 (intermediate) and 3 (external). CONCLUSIONS: Regarding granuloma as a whole, we may conclude that fibrosis is likely to be controlled by different and independent mechanisms in the three zones of the granuloma. Lamellar fibrosis in zone 3 seems to be controlled by matrix mesenchymal cells (fibroblasts and myoepithelial cells) and by inflammatory exudate cells (lymphocytes, plasmocytes, neutrophils, eosinophils). Annular fibrosis in zone 2, comprising a dense fibrous connective tissue, with few cells in the advanced phase, would be controlled by epithelioid cells involving zone 1 in recent granulomas. In zone 1, replacing periovular necrosis, an initialy loose and tracery connective neoformation, housing stellate cells or with fusiform nuclei, a dense paucicellular nodular connctive tissue emerges, probably induced by fibroblasts. In several granulomas, one of the zones is missing and granuloma is represented by two of them: Z3 and Z2, Z3 and Z1 or Z2 and Z1 and, ultimately, by a scar.

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