Hepatitis B virus infection in children, adolescents, and their relatives: genotype distribution and precore and core gene mutations

Revista da Sociedade Brasileira de Medicina Tropical

Adriana Parise Compri²  Irene Miura¹  Gilda Porta¹  Marcilio Figueiredo Lemos²  Cláudia Patara Saraceni²  Regina Célia Moreira² 

[1] ,Instituto Adolfo Lutz Laboratório de Hepatites Virais São Paulo SP

关键词: Hepatitis B;    Genotype;    Mutation;    Vertical transmission;    Horizontal transmission;    Hepatite B;    Genótipo;    Mutação;    Transmissão vertical;    Transmissão horizontal;   

DOI  :  10.1590/S0037-86822012000300004

来源: SciELO

【 摘 要 】

INTRODUCTION:The objectives of this study were evaluate hepatitis B virus (HBV) serological markers in children and adolescents followed up at the Child Institute of the Hospital das Clínicas, Faculdade de Medicina de São Paulo, Universidade de São Paulo; identify chronic HBV carriers and susceptible individuals in the intrafamilial environment; characterize HBV genotypes; and identify mutations in the patients and household contacts. METHODS: Ninety-five hepatitis B surface antigen-positive children aged <19 years and 118 household contacts were enrolled in this study. Commercial kits were used for the detection of serological markers, and PCR was used for genotyping. RESULTS: Hepatitis B e antigen (HBeAg) was detected in 66.3% (63/95) of cases. Three of the 30 HBeAg-negative and anti-HBeAg-positive patients presented with precore mutations and 11 presented with mutations in the basal core promoter (BCP). Genotype A was identified in 39 (43.8%) patients, genotype D in 45 (50.6%), and genotype C in 5 (5.6%). Of the 118 relatives, 40 were chronic HBV carriers, 52 presented with the anti-HBc marker, 19 were vaccinated, and 7 were susceptible. Among the relatives, genotypes A, D, and C were the most frequent. One parent presented with a precore mutation and 4 presented with BCP mutations. CONCLUSIONS: Genotypes A and D were the most frequent among children, adolescents, and their relatives. The high prevalence of HBV in the families showed the possibility of its intrafamilial transmission.

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