Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients

Revista da Sociedade Brasileira de Medicina Tropical

Guenael Freire De Souza²  Fernando Biscione²  Dirceu Bartolomeu Greco²  Ana Rabello¹ 

[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Belo Horizonte MG

关键词: Visceral leishmaniasis;    HIV;    Coinfection;    Treatment;    Leishmaniose visceral;    HIV;    Co-infecção;    Tratamento;   

DOI  :  10.1590/S0037-86822012000200001

来源: SciELO

【 摘 要 】

INTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care settings in Belo Horizonte, Brazil. RESULTS: At baseline, the clinical picture was similar between both groups, although diarrhea and peripheral lymphadenomegaly were more frequent in HIV-infected subjects. HIV-positive patients had lower median blood lymphocyte counts (686/mm³ versus 948/mm³p = 0.004) and lower values of alanine aminotransferase (ALT) (48IU/L versus 75.6IU/L p = 0.016) than HIV-negative patients. HIV-positive status (hazard ratio = 0.423, p = 0.023) and anemia (HR = 0.205, p = 0.002) were independent negative predictors of complete clinical response following antileishmanial treatment initiation. CONCLUSIONS: This study reinforces that all patients with VL should be tested for HIV infection, regardless of their clinical picture. This practice would allow early recognition of coinfection with initiation of antiretroviral therapy and, possibly, reduction in treatment failure.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License