Prevalence of hepatitis A virus infection: the paradoxical example of isolated communities in the western Brazilian Amazon region

Revista da Sociedade Brasileira de Medicina Tropical

Wornei Silva Miranda Braga²  Fabiane Giovanella Borges²  Gildo Maia Barros Júnior²  Ana Cristina De Souza Martinho²  Ivo Seixas Rodrigues²  Eliete Pereira De Azevedo²  Gustavo Henrique Nolasco Grimmer Davis¹  Manoel Bezerra De Queiroz¹  Simone Helena Derzi Dos Santos¹  Thiago Vitoriano Barbosa¹  Márcia Da Costa Castilho² 

[1] ,Tropical Medicine Foundation of Amazonas Virology Unit Manaus AM ,Brazil

关键词: Hepatitis A virus;    Epidemiology;    Prevalence;    Amazon region;    Brazil;    Vírus da hepatite A;    Epidemiologia;    Prevalência;    Região amazônica;    Brasil;   

DOI  :  10.1590/S0037-86822009000300008

来源: SciELO

【 摘 要 】

This study evaluated the prevalence of hepatitis A virus infection in the rural area of Lábrea, in the western Brazilian Amazon region. Communities and households were selected randomly. Serum samples were analyzed by means of the immunoenzymatic method for the presence of total antibodies against HAV. The study included 1,499 individuals. The prevalence of anti-HAV was 74.6% (95% CI 72.3-76.8). Univariate analysis showed associations with age (chi-square for linear trend = 496.003, p < 0.001), presence of outside toilet (p < 0.001), history of hepatitis (p < 0.001) and family history of hepatitis (p = 0.05). After adjusting for age, HAV infection also showed an association with the number of people in the family (p = 0.03). The overall prevalence rates were high, but not more than 60% of the children under the age of ten years had already been infected. Very high prevalence was detected only within older cohorts, thus paradoxically defining this as a region with intermediate endemicity, even under the conditions of poverty encountered.

【 授权许可】

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