Adverse reactions associated with a Fuenzalida-Palacios rabies vaccine: a quasi-experimental study

Revista da Sociedade Brasileira de Medicina Tropical

Rosuita Fratari Bonito¹  Neide Mattar De Oliveira¹  Sérgio De Andrade Nishioka¹ 

[1] ,Universidade Federal de Uberlândia Faculdade de Medicina Departamento de Clínica MédicaUberlândia MG ,Brazil

关键词: Adverse reaction;    Fuenzalida-Palacios vaccine;    Post-exposure prophylaxis;    Quasi-experimental study;    Rabies vaccine;    Estudo quase-experimental;    Profilaxia pós-exposição;    Reação adversa;    Vacina anti-rábica;    Vacina Fuenzalida-Palacios;   

DOI  :  10.1590/S0037-86822004000100002

来源: SciELO

【 摘 要 】

The Fuenzalida-Palacios rabies vaccine has been used in South America for rabies post-exposure prophylaxis. To determine the frequency of adverse reactions associated with this vaccine compared to a control group a quasi-experimental study was carried out in Uberlândia, Brazil, from May 1997 to April 1998. Victims of bites or other injuries by dogs or other mammals and who received or not post-exposure prophylaxis with Fuenzalida-Palacios rabies vaccine were compared as to the occurrence of a list of signs and symptoms. Out of 2,440 victims of bites and other injuries from dogs and other mammals 2,114 participated in the study; 1,004 of them provided follow-up information within 10 to 15 days. Headache and pain at the injection sites were the most commonly found symptoms (125/1,000). No neuroparalytic event was detected. Patients who were given Fuenzalida-Palacios rabies vaccine and those who were not had similar incidences of symptoms (risk ratios close to 1). Regarding the occurrence of adverse reactions, Fuenzalida-Palacios rabies vaccine is a valid alternative for rabies post-exposure prophylaxis.

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