Acute liver failure in children: observations in Vitória, Espírito Santo State, Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Sandra F. Moreira-silva²  Diana O. Frauches²  Alba L. Almeida²  Haydée F.m.s. Mendonça²  Fausto Edmundo L. Pereira¹ 

[1] ,Hospital Infantil Nossa Senhora da GlóriaVitória ES

关键词: Fulminant hepatitis;    Liver failure;    Acute hepatitis;    Hepatitis A;    Hepatitis;    Hepatite fulminante;    Insuficiência hepática;    Hepatite aguda;    Hepatite A;    Hepatite;   

DOI  :  10.1590/S0037-86822002000500010

来源: SciELO

【 摘 要 】

In this communication we report 46 cases of acute liver failure in children diagnosed at the Hospital Infantil Nossa Senhora da Glória in Vitória, E Santo. Serology for IgM anti-HAV, IgM anti-HBc, HbsAg, anti-HCV and biochemical tests were performed in all cases in a routine laboratory. The M/F ratio was 1.1:1 and the mean age was 4.7±3.2 years, without gender difference. Anti-HAV IgM+ in 38 (82.6%) cases, anti-HbcIgM+ in two (4.3 %) cases and 6 (13.1%) cases were negative for all viral markers investigated. Anti- HCV+ in one anti-HAV IgM+ case. HbsAg+ in two anti-HbcIgM+ and in two HAVIgM+ cases. Among the six A, B and C negative cases, four (8.6%) did not have the suspected exogenous intoxication. Mortality was 50%, without gender or age differences. These results demonstrate that HAV infection is the main etiology of acute liver failure in children in Brazil, confirming that, although it is a self limited, relatively mild illness, it can cause serious and even fatal disease. The observation of four cases without A, B and C viral markers and no history of exogenous intoxication, agree with the observation of non A-E acute sporadic hepatitis in Northeastern Brazil.

【 授权许可】

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