Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania

Revista da Sociedade Brasileira de Medicina Tropical

Wilson Mayrink²  Gilmara Cristina Dos Santos²  Vicente De Paulo Coelho Peixoto De Toledo¹  Tânia Mara Pinto Dabés Guimarães¹  George Luis Lins Machado-coelho¹  Odair Genaro¹  Carlos Alberto Da Costa¹ 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Biológicas Departamento de ParasitologiaBelo Horizonte MG

关键词: Leishmania;    Vaccine;    Interferon-gamma;    Interleukin-4;    Leishmania;    Vacina;    Interferon-g;    Interleucina-4;   

DOI  :  10.1590/S0037-86822002000200001

来源: SciELO

【 摘 要 】

Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.

【 授权许可】

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