Human parvovirus B19 infections among exanthematic diseases notified as measles

Revista da Sociedade Brasileira de Medicina Tropical

Rita C.n. Cubel²  Marilda M. Siqueira¹  Elisabete O. Santos¹  Maria F. Pires¹  Célia M. F. Cruz¹  Jussara P. Nascimento¹ 

[1] ,FIOCRUZRio de Janeiro RJ ,Brasil

关键词: Human parvovirus B19;    Exanthematic disease;    Measles;    Rubella;    Parvovírus Humano B19;    Doença Exantemática;    Sarampo;    Rubéola;   

DOI  :  10.1590/S0037-86821997000100004

来源: SciELO

【 摘 要 】

A total of 1397 sera collected from 1095 cases of exanthematic disease notified as measles in ES and RJ states during July 1992 to December 1994 were investigated. These sera were first tested for measles and rubella specific IgM. When they proved negative, they were tested for B19 specific IgM by an enzyme immunoassay. B19 infection was confirmed in 27 (2.5%) of these cases. Sera from 194 negative cases for measles and rubella IgM received from other Brazilian states were also investigated and B19 infection was confirmed for 11 of them. Sera from these 38 IgM positive cases for B19, were tested for anti-B19 IgG by an enzyme immunoassay and for B19 DNA by dot blot hybridization. Anti-B19 IgG antibodies were detected in most of the acute sera. B19 DNA was detected in the acute serum of one patient that had been splenectomized before. As the exanthem caused by human parvovirus infection may be clinically diagnosed as rubella, it could be important to diagnose B19 infection in Brazil since it is becoming prevalent as the cause of rash in countries where rubella is controlled by vaccination.

【 授权许可】

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