Liver and serum soluble protein changes and pathomorphology in undernourished mice with acute Schistosomiasis mansoni

Revista da Sociedade Brasileira de Medicina Tropical

Eridan M. Coutinho¹  Frederico G. C. Abath¹  Lucila P. C. G. De Freitas¹  Aureni C. Salzano¹  Maria A. Lapa¹  Florisbela S. Campos¹  Eliane B. Melo¹ 

关键词: Schistosoma mansoni;    Malnutrition;    Mice;    Proteins;    Schistosoma mansoni;    Desnutrição;    Proteínas;    Camundongo;   

DOI  :  10.1590/S0037-86821991000400006

来源: SciELO

【 摘 要 】

Body, liver and spleen weights; histopathology of the liver, spleen and intestines; hepatic and serum soluble proteins changes were the parameters studied in undernourished Swiss albino mice experimentally infected with S. mansoni. Non-infected deficient animab had lower liver/body weight and spleen/body weight ratios as compared to the controls (22.60% casein group). Infected mice showed higher values regardless the type of diet. Undernourished infected subgroup showed a persistent exudative periovular reaction in the liver. Soluble hepatic proteins content and serum protein fractions appeared to be lower in the deficient infected mice. A significant difference was detected in the gammaglobulin fraction between infected and non-infected animals fed the control diet with higher values for the former. Our data suggest that the effects of malnutrition, per se, are sometimes more detrimental to the host than those due to Manson 's schistosomiasis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License