EFFECTS OF VITAMIN C SUPPLEMENTATION ON THE CHRONIC PHASE OF CHAGAS DISEASE

Revista do Instituto de Medicina Tropical de São Paulo

Ricardo Guimarães Marim¹  Alex Silva De GusmÃo¹  Roberto Esteves Pires Castanho¹  Rafael Deminice¹  Altino Luiz Silva Therezo¹  Alceu Afonso JordÃo JÚnior¹  Marcos Renato De Assis¹  Elane De Fátima Taipeiro¹  Luciamare Perinetti Alves Martins¹ 

关键词: Lipid peroxidation biomarkers;    Chagas disease;    Parasitemia;    Inflammation;    Ascorbic acid;    ROS;    RNS;   

DOI  :  10.1590/S0036-46652015000300011

来源: SciELO

【 摘 要 】

Introduction:In order to examine the effectiveness of vitamin C (ascorbic acid) in combating the oxidative insult caused by Trypanosoma cruzi during the development of the chronic phase of Chagas disease, Swiss mice were infected intraperitoneally with 5.0 × 104 trypomastigotes of T. cruzi QM1strain.Methods:Mice were given supplements of two different doses of vitamin C for 180 days. Levels of lipid oxidation (as indicated by thiobarbituric acid reactive substances-TBARS), total peroxide, vitamin C, and reduced glutathione were measured in the plasma, TBARS, total peroxide and vitamin C were measured in the myocardium and histopathologic analysis was undertaken in heart, colon and skeletal muscle.Results:Animals that received a dose equivalent to 500 mg of vitamin C daily showed increased production of ROS in plasma and myocardium and a greater degree of inflammation and necrosis in skeletal muscles than those that received a lower dose or no vitamin C whatsoever.Conclusion:Although some research has shown the antioxidant effect of vitamin C, the results showed that animals subject to a 500 mg dose of vitamin C showed greater tissue damage in the chronic phase of Chagas disease, probably due to the paradoxical actions of the substance, which in this pathology, will have acted as a pro-oxidant or pro-inflammatory.

【 授权许可】

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