FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE

Revista do Instituto de Medicina Tropical de São Paulo

Cláudia Maria Valete-rosalino¹  Maria Helena Araujo-melo¹  Débora Cristina De Oliveira Bezerra¹  Renata Oliveira De Barcelos¹  Vanessa De Melo-ferreira¹  Tânia Salgado De Sousa Torraca¹  Ana Cristina Da Costa Martins¹  João Soares Moreira¹  Mirian Catherine Melgares Vargas¹  Frederico Pereira Bom Braga¹  Mariza De Matos Salgueiro¹  Maurício Naoto Saheki¹  Armando Oliveira Schubach¹ 

关键词: Mucocutaneous Leishmaniasis;    Drug Toxicity;    Meglumine antimoniate;    Hearing loss;    Tinnitus;    Dizziness;   

DOI  :  10.1590/S0036-46652014000500012

来源: SciELO

【 摘 要 】

Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.

【 授权许可】

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