BIOPSY PROVEN ACUTE TUBULAR NECROSIS DUE TO RHABDOMYOLYSIS IN A DENGUE FEVER PATIENT: A CASE REPORT AND REVIEW OF LITERATURE

Revista do Instituto de Medicina Tropical de São Paulo

Liliany P. Repizo¹  Denise M. Malheiros¹  Luis Yu¹  Rui T. Barros¹  Emmanuel A. Burdmann¹ 

关键词: Dengue fever;    Acute kidney injury;    Acute tubular necrosis;    Renal histology;    Myoglobin;    Rhabdomyolysis;    Creatine phosphokinase;   

DOI  :  10.1590/S0036-46652014000100014

来源: SciELO

【 摘 要 】

Renal histology results are very scarce in dengue-associated rhabdomyolysis patients developing acute kidney injury (AKI). We report a case of dengue fever-induced AKI associated to rhabdomyolysis with a renal biopsy showing acute tubular necrosis (ATN) and renal deposition of myoglobin. A 28-year-old patient who presented dengue fever (DF) complicated by severe AKI and rhabdomyolysis is described. The patient required hemodialysis for three weeks. A renal biopsy revealed ATN with positive staining for myoglobin in the renal tubuli. The patient was discharged with recovered renal function. In conclusion, this case report described a biopsy proven ATN associated to DF-induced rhabdomyolysis, in which renal deposition of myoglobin was demonstrated. We suggest that serum creatine phosphokinase should be monitored in DF patients to allow for an early diagnosis of rhabdomyolysis and the institution of renal protective measures.

【 授权许可】

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