Prevalence of intestinal microsporidiosis in Human Immunodeficiency Virus-infected patients with diarrhea in major United States cities

Revista do Instituto de Medicina Tropical de São Paulo

Mark S. Dworkin²  Susan E. Buskin¹  Arthur J. Davidson¹  David L. Cohn¹  Anne Morse¹  Jeffrey Inungu¹  Michael R. Adams²  Scott B. Mccombs²  Jeffrey L. Jones¹  Hercules Moura¹  Govinda Visvesvara¹  Norman J. Pieniazek¹  Thomas R. Navin¹ 

[1] ,National Center for HIV, STD, and TB Prevention

关键词: Intestinal microsporidiosis;    Prevalence;    HIV-infected patients;    Diarrhea;   

DOI  :  10.1590/S0036-46652007000600001

来源: SciELO

【 摘 要 】

To determine the prevalence of intestinal microsporidiosis in HIV-infected patients, we performed a prospective study of HIV-infected patients with diarrheal illnesses in three US hospitals and examined an observational database of HIV-infected patients in 10 US cities. Among 737 specimens from the three hospitals, results were positive for 11 (prevalence 1.5%); seven (64%) acquired HIV through male-to-male sexual contact, two (18%) through male-to-male sexual contact and injection drug use, and one (9%) through heterosexual contact; one (9%) had an undetermined mode of transmission. Median CD4 count within six months of diagnosis of microsporidiosis was 33 cells/µL (range 3 to 319 cells/µL). For the national observational database (n = 24,098), the overall prevalence of microsporidiosis was 0.16%. Prevalence of microsporidiosis among HIV-infected patients with diarrheal disease is low, and microsporidiosis is most often diagnosed in patients with very low CD4+ cell counts. Testing for microsporidia appears to be indicated, especially for patients with very low CD4+ cell counts.

【 授权许可】

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